| 16.30 – 18.30 | Arrival, Registration and Check-in

| 18.30 – 18.55 | Welcome address

| 19.00 – 19.45 | Keynote Lecture:  Víctor Torres, St. Jude Children's Research Hospital, USA. Unmasking the secrets of the staphylococcal bi-component leukocidins

| 20.00 – 23.00 | Dinner & Social at Hotel ARANTZAZU

Session 1 - Bacterial Toxins I
Chair: Daniel Humphreys

| 9.00 – 9.30 | Jorge E. Galán, Yale School of Medicine, USA. Understanding Typhoid fever: from pathognomonic symptoms to host specificity.

| 9.30 – 9.45 | Shihui Liu,  University of Pittsburgh, USA. Caveolin-1 is a receptor mediating cytolytic activity of Bacillus cereus hemolysin BL toxin

| 9.45 – 10.00 | María Lopez Chiloeches,  Umeå University, Sweden. How does a DNA-damaging strain of Salmonella enterica contribute to colon cancer development in vivo? 

| 10.00 – 10.30 | Armelle M. Menard, Université de Bordeaux, France. How bacterial genotoxins fuel digestive cancer. 

| 10.30 – 11:00 | Coffee Break

Chair: Asaf Levy

| 11.00 – 11.30 | Sophie Helaine, Harvard Medical School, USA. Role of toxins in Salmonella persistence during infection

| 11.30 – 12.00 | Joseph Mougous, University of Washington, USA. Determinants of cell targeting by Streptomyces umbrella toxins 

| 12.00 – 12.15 | Despoina Mavridou,   University of Texas, USA. Colicin plasmids highjack the lipoprotein biogenesis machinery for toxin delivery

| 12.15 – 12.30 | Andreas Rummel, Hannover Medical School, Germany. Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47 

| 12.30 – 13.15 | POSTER PREVIEW (odd numbers)
 

| 13.30 – 15.30 | Standing lunch & Poster session 1 at ArantzazuLAB

Session 2 - T3SS-dependent effectors and toxins 
Chair: Denise Monack

| 16.00 - 16.30  | Samuel Wagner, Tübingen University, Germany. Secretion of transmembrane effectors by T3SS and T4bSS

| 16.30 – 16.45 | Ines Diaz-del-Olmo, University of Oxford, UK.

Macrophage transcriptional reprogramming by the SteE-STAT3 axis 

 
| 16.45 – 17.15 | Elizabeth L. Hartland, Hudson Institute of Medical Research, Australia. Cell intrinsic immunity to intracellular bacteria 

| 17.15 – 17.45 | Coffee Break

| 17.45 – 18.15 | Kim Orth, UT Southwestern Medical School, USA. A critical role of Vibrio parahaemolyticus LpxM in LPS-mediated evasion of host immune response during infection 
 
| 18.15 – 18.30 | Joaquin Bernal-Bayard, Universidad de Sevilla, Spain.

Salmonella enterica NEL ubiquitin ligases: reprogramming cellular processes for successful infection 

| 18.30 – 18.45 | Qiyun Zhong, Institute of Cancer Research, UK. High-content live imaging and AI analysis of single cell NF-κB dynamics manipulation by EPEC T3SS effectors 

| 20.00 | Standing Dinner & Social at ArantzazuLAB

Session 3 - Bacterial Toxins II 

Chair: Carmen Buchrieser

| 9.00 - 9.30  |  Karla Satchell, Northwestern University Feinberg School of Medicine, USA. MARTX toxin surface Interactions and signal collisions during cell intoxication

| 9.30 – 9.45 | Sandra Sousa, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal. Protective role of pneumolysin-induced cytoskeletal and organelle remodeling during pneumococcal infection

| 9.45 – 10.15 | Carmen Amaro, Universidad de Valencia, Spain. Beyond Invasion: A Lethal Role for the MARTX Toxin in Fish Septicemia

| 10.15 – 10.30 | Eva Slivenecka, Institute of Microbiology, Czech Academy of Sciences.

The Actinobacillus pleuropneumoniae apxIV operon encodes an antibacterial toxin-immunity pair 

| 10.30 – 11.00 | Coffee Break

Chair: Teresa Frisan

| 11.00 – 11.30 | Peter Sebo, Institute of Microbiology, Czech Academy of Sciences. Adenylate cyclase toxin and virulence of the pertussis agent 

  
| 11.30 – 11.45 | Seongmi K. Russell, Washington University School of Medicine, USA. Early-Life Enterotoxigenic Bacteroides fragilis Acquisition and Colorectal Cancer Risk 

| 11.45 – 12.00 | Jueqi Chen, University of Chicago, USA. Type I but not type II cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation 

| 12.00 – 12.30 | Sun Nyunt Wai, Umeå University, Sweden. Modulation of cancer cell signalling by secreted bacterial factors

| 12.30 – 13.00 |  Nuno dos Santos, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal. AIP56 and "AIP56 family" toxins: substrate and receptor specificity

| 13.00 – 13.30 | POSTER PREVIEW (even numbers)

| 13.30 – 15.30 |  Standing lunch & Poster session 2 at ArantzazuLAB

Session 4 - T4SS-dependent effectors
Chair:  Christoph Dehio

 | 16.00 – 16.30 | Gabriel Waksman, University College London, UK. Structural and molecular biology of pilus biogenesis by conjugative type IV secretion systems

| 16.30 – 16.45 | Matteo Bonazzi, Institut de Recherche en Infectiologie de Montpellier, France. The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery 

| 16.45 – 17.00 | Gunnar Schroeder, Queen’s University Belfast, UK. Characterisation of Legionella T4SS glycosyltransferase effectors 

 | 17.00 – 17.30 | Leo Eberl, University of Zurich,  Switzerland. The kib locus of Pseudomonas putida IsoF encodes a type IVB secretion system-based killing nanomachine required for biofilm invasion and biocontrol

| 17.30 – 18.00 | Coffee Break

Session 5 - T5SS-dependent toxins/effectors
Chair:  Luke Allsopp

| 18.00 – 18.30 | Peggy Cotter, University of North Carolina at Chapel Hill, USA. New insight into the secretion and function of Two-Partner Secretion pathway proteins from studies on FhaB in Bordetella species

| 18.30 – 19.00 | Christopher S. Hayes, University of California, Santa Barbara, USA. Bordetella use a novel microtubule-binding domain to colonize the motile cilia of respiratory epithelia 

| 20.00 | Dinner & Social at Hotel ARANTZAZU

Session 6 - T6SS-dependent toxins
Chair: Marek Basler

| 9.00 – 9.30 | Eric Cascales, Laboratoire d'Ingénierie des Systèmes Macromoléculaires, France. Architecture, Assembly and Mechanism of Action of a bacterial nanoweapon: the type VI secretion system

| 9.30 – 9.45 | Daniel Unterweger, Kiel University, Germany. Type VI secretion system apparatus and effector genes 

in a global population of Pseudomonas aeruginosa

 
| 9.45 – 10.15 | Dor Salomon, Tel Aviv University, Israel. A bipartite T6SS delivery domain defines a new class of peptidoglycan-targeting effectors
 
| 10.15 – 10.30 | Alix Lee, Queen's University Belfast, UK. Single amino acid polymorphism dictates the offensive versus defensive type VI secretion system behaviour affecting horizontal gene transfer in Klebsiella pneumoniae

| 10.30 – 11.00 | Coffee Break

Chair: Joseph Mougous

| 11.00 – 11.30 |  Alain Filloux, Nanyang Technological University, Singapore. Cryo-EM Structure of Hcp-Tce1 Reveals the Mechanism of Effector Loading and Delivery by the T6SS

| 11.30 – 11.45 | Luke Allsopp, Imperial College London, UK. Tsd1 and Tne3 are new T6SS effectors of clinical Pseudomonas aeruginosa isolates 

| 11.45 – 12.15 | Sarah Coulthurst, University of Dundee, UK. Diverse antimicrobial effectors delivered by the Type VI secretion system of Serratia marcescens

| 12.15 – 12.30 | Lucas Cesetti, Université de Genève, Unige, Switzerland, Xanthomonas citri employs diverse strategies to evade predation by amoebae 

| 12.30 – 12.45 | Steven Kelly, McMaster University, Canada. A Conserved Hotspot in the Pseudomonas aeruginosa H3-Type VI Secretion System Encodes Anti-Eukaryotic Effectors 

| 12.45 – 13.00 |  Ezequiel Valguarnera, Washington University in Saint Louis, USA. An ubiquitous toxin from human gut commensals promotes neonatal competitive advantage 

| 13.00 – 14.00 | Lunch at Hotel SINDIKA

| 15.30 | Group activities

| 20.00 | ETOX 2025 closing dinner

Emerging Scientists
Chair: Eran Bosis

| 9.00 – 9.12 |  Julia Monjaras-Feria, Queen's University Belfast, UK.

Burkholderia Lethal Factor 1 is secreted by a system-independent pathway and directed to membrane vesicles 

| 9.13 – 9.25 |  Miguel Lopez, University of Zurich, Switzerland. Deciphering a novel Type IVB Secretion System involved in interbacterial killing 

| 9.26 – 9.38 |  Pin-Yi Song, Institute of Molecular Biology, Academia Sinica, Taiwan. Mechanistic insights of a T6SS-associated cysteine protease effector targeting the type II topoisomerases GyrB and ParE

| 9.39 – 9.51 |  Dmitry Shatskiy,  University of Groningen, Netherlands. Structural basis of F-tractin–F-actin interaction: implications for actin visualization and toxin studies 

| 9.52 – 10.04 |  Hoi Ching Cheung, Biozentrum, Switzerland. Switching between anti-bacterial and anti-eukaryotic Type VI Secretion Systems of Burkholderia thailandensis 

| 10.05 – 10.17 |  Salma Sour, University of Sheffield, UK.  Typhoid toxin of Salmonella Typhi elicits host antibacterial response during acute typhoid fever

| 10.18 – 10.30 |  Yung-Hui Victoria Wen. Institute of Plant and Microbial Biology, Academia Sinica, Taiwan. Unraveling the role of the ClpAPS protease complex in enhancing Agrobacterium type VI secretion system-mediated killing: Insights into Recipient Susceptibility Factors 

| 10.30 – 11.00 | Coffee Break

Session 7 - T7SS-dependent toxins
Chair: Jorge Galán

| 11.00 – 11.30 |  Tracy Palmer, Newcastle University, UK. Distinct immunity protein families mediate compartment-specific neutralisation of a bacterial
toxin

Keynote Lecture

| 11.30 – 12.15 | Denise Monack, Stanford University School of Medicine, USA. Phase-variable receptors and prophage-encoded defense drive lineage-specific Salmonella–phage interactions

| 12.15 – 12.30 |  Close from Organizers and ETOX 2027 announcement

| 12.45 – 13.30 | Lunch at Hotel SINDIKA 

| 14.00 |  Buses depart