| 15:00 – 17.45 | Arrival, Registration and Check-in,

| 17.45 – 18.00 | Welcome address

| 18.00 – 19.00 | The EMBO Keynote Lecture:  Stefan Raunser, MPI of Molecular Physiology, Germany. Mechanism of Action of Tc Toxins: Protein Translocation Through Bacterial Syringes

| 19.00 | Dinner and informal evening social

Session 1 - Mechanism of toxin effectors and their secretion systems 
Chair: Laure Journet

| 9.00 – 9.30 | Martin Pilhofer, ETH Zurich, Switzerland. Structure, function and evolution of bacterial contractile injection systems

| 9.30 – 9.45 | Jana Kamanova, Czech Academy of Sciences, Czech Republic. Assembly and function of the needle tip filament of the Bordetella type III secretion system
 
| 9.45 – 10.15 |  Alain Filloux, Imperial College London, UK. Pull-down of effectors with Hcp rings and structural details of T6SS onboarding.

| 10.15 – 10.30 |  Somnath Dutta, Indian Institute of Science, India. Deciphering the structural reorganization of bacterial pore forming toxins on lipid bio membranes using single particle Cryo-EM

| 10.30 – 10.45 | Poster mini talks 

Jonathan Pruneda, Oregon Health & Science University, USA

Alexander Belyy, Max Planck Institute of Molecular Physiology, Germany

Katharina Kubatzky, Heidelberg University, Germany

| 10.45 – 11:15 | Coffee Break

| 11.15 – 11.45 | John Whitney, McMaster University, Canada. Toxin export by the bacterial type VIIb secretion system

| 11.45 – 12.00 | Alex Johnson, Harvard Medical School, USA. Cryo-EM structure of an active bacterial gasdermin oligomer

| 12.00 – 12.15 | Benjamin Aroeti, University of Jerusalem, Israel. EspH – The Mechanism of Action

| 12.15 – 12.45 | Marek Basler, Biozentrum Basel, Switzerland. Spatial and temporal regulation of Type 6 Secretion System dynamics during interactions with bacterial and eukaryotic cells

| 12.45 – 13.00 | Poster mini talks 

Stefanie Lietz, Ulm University Medical Center, Germany

Angélique Perret, Université de Genève, Switzerland

Hoi Ching Cheung, University of Basel, Switzerland

| 13:00 – 14:30 | Lunch

Session 2 - Host Responses and Immunity 
Chair: Karla Satchell

| 14.30 - 15.00  | Charlotte Odendall,  Kings College London, UK. Interferon:Tug of War between Host and Pathogen

| 15.00 – 15.15 | Kim Robinson, Nanyang Technological University, Singapore. Corynebacterium diphtheriae causes ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria
 
| 15.15 – 15.45 | Laurent Boyer, Université Côte d'Azur, France. Innate immune sensing of RhoGTPase-activating bacterial toxins

| 15.45 – 16.00 | Poster mini talks 

Panagiotis Papatheodorou (Ulm University Medical Center, Germany)

Shihui Liu (University of Pittsburgh School of Medicine, USA)

Paweena Chaoprasid (University of Münster, Germany)

| 16.00 – 16.30 | Coffee Break

| 16.30 – 16.45 | Etienne Meunier, University of Toulouse, France. EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection   

Lecture supported by the Microbiology Society
| 16.45 – 17.20 | Feng Shao, National Institute of Biological Sciences,  China. Hijacking the LPS-sensing noncanonical inflammasome pathway by bacterial effectors

| 17.20 – 17.45 | Poster mini talks 

Andreas Rummel, Hannover Medical School, Germany

Rachel Prescott. New York University Grossman School of Medicine

Oleg Sitsel, Max-Planck Institute of Molecular Physiology, Germany

Pablo Ezequiel Valguarnera, Washington University, USA

Shivneet Gill, University of Toronto, Canada

| 17.45 – 18.15 | Panel Discussion

Title: Tbc

| 19:00 | Dinner

| 20:00 | Posters and social

Session 3 - Divergent roles of bacterial effectors and toxins 

Chair: Vassilis Koronakis

| 9.00 – 9.30 | Bart Thomma, University of Cologne, Germany. Plant pathogens manipulate host microbiota to promote disease development

| 9.30 – 9.45 | Elena Kudryashova, Ohio State University, USA. Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL revealed by single-molecule imaging 

| 9.45 – 10.15 | Ethel Bayer-Santos, University of São Paulo, Brazil. The Salmonella T6SS arsenal to overcome colonization resistance

| 10.15 – 10.30 | David Albesa-Jové, University of the Basque Country, Spain. The Pseudomonas aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria

| 10.30 – 10.45 | Poster mini talks 

Mohamed El Ghazaly, University of Sheffield, UK

Filippo Cattalani Tognola, University of Bern, Germany

Michal Bejerano-Sagie, Hebrew University of Jerusalem, Israel

| 10.45 – 11:15 | Coffee Break

| 11.15 – 11.45 |  Neal Alto,  University of Texas Southwestern Medical Center, USA. Mapping Effector Protein Functions at Single Cell Resolution

| 11.45 – 12.00 | Seema Mattoo, Purdue University, USA. Fic-mediated GMPylation: Discovery of a Bordetella Fic protein with guanylyltransferase activity

| 12.00 – 12.30 | Jeongmin Song, Cornell University, USA. Salmonella AB toxins: biology, pathogenesis, and neutralization

| 12.30 – 12.45 | Dorothea Höpfner, University Medical Center Hamburg-Eppendorf, Germany. The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic-enzyme targets Histone H3  
 
| 12.45 – 13.00 | Poster mini talks 

Laure Journet, Aix Marseille University, France

Sandra Sousa, Universidade do Porto, Portugal

Michael Costello, University of California, USA

| 13:00 – 14:30 | Lunch

Session 4 - Bacterial toxins against bacteria
Chair: Christoph Tang

Lecture supported by the National Biofilms Innovation Centre
| 14.30 - 15.00  |  Laurie Comstock, University of Chicago, USA. Title: Tbc

| 15.00 – 15.15 | Benjamin Ross, Dartmouth College Geisel School of Medicine, USA. Defense against the Bacteroidales type VI secretion system is mediated by recombinase-associated acquired interbacterial defense orphan immunity genes
 
| 15.15 – 15.45 | Tim Blower, University of Durham, UK. Slowing down to get ahead: self-targeting toxins of Mycobacterium tuberculosis
 
| 15.45 – 16.00 | Poster mini talks 

John Manion, Harvard Medical School, USA

Gunnar Schroeder, Queen’s University Belfast, UK

Charles Ericson, ETH Zürich, Switzerland

| 16.00 – 16.30 | Coffee Break

| 16.30 – 17.00 | Marion Schuller, University of Oxford, UK. Molecular basis and cellular consequences of DNA base ADP-ribosylation by the bacterial toxin DarT

 
Keynote lecture supported by Microbiology Society
| 17.00 – 18.00 | Chris Hayes, University of California, USA. Break on through (to the other side): Delivery of type V secretion system effector domains into target cells

| 19:00 | Dinner

| 20:00 | Posters and social

Session 5 - Host-Pathogen Interactions
Chair: Joe Barbieri

| 9.00 – 9.30 | Suzana Salcedo, University of Lyon, France. Studying TIR effectors in the context of bacterial pathogenesis
 
| 9.30 – 10.00 | Jost Enninga, Institut Pasteur, France. Investigating Shigella intracellular niche formation in situ at molecular resolution

Lecture supported by the journal Molecular Microbiology
| 10.00 – 10.30 | Teresa Thurston, Imperial College London. Bacterial effectors and their many ways to modulate immune signaling

| 10.30 – 11:00 | Coffee Break

| 11.00 – 11.30 | Tamara O’Connor, Johns Hopkins University School of Medicine, USA. The bacterial pathogen Legionella hijacks host cell peroxisomes for replication vacuole membrane expansion and integrity

| 11.30 – 11.45 |  Anthony Davidson, University of Cambridge, UK. Salmonella invasion is self-limiting due to effector-driven activation of N-WASP

| 11.45 – 12.15 | Carmen Buchreiser, Institut Pasteur, France. Transkingdom signalling via Legionella pneumophila small regulatory RNAs  and extracellular vesicles

| 12.15 – 13:00 | Lunch

| 13:00 – 18:00 | Choice of activities, or free time to explore the resort

| 19.00 – late | Conference Dinner and Scottish Ceilidh

Session 6 - New perspectives on bacterial toxins and effectors
Chair: Peter Sebo

Session 6 is supported by the Biochemical Society

| 9.00 – 9.30 | Emmanuel Lemichez, Institut Pasteur, France. The cnf1 toxin encoding gene confers a competitive advantage for gut colonization by ExPEC 

| 9:30 – 9:45 |  Rebecca McHugh, University of Glasgow, UK. Repurposing Aurodox as an Antivirulence Treatment for Shiga-toxin-Producing E. coli Infections.

| 9:45 – 10:00 | Nimrod Nachmias, Hebrew University of Jerusalem, Israel. Systematic Discovery of Antibacterial and Antifungal Bacterial Toxins 

| 10.00 – 10:30 | Coffee Break

| 10:30 – 10.45 | Shan Li, Huazhong Agricultural University, China. Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases

| 10:45 – 11.00 | Eric Oswald, Université de Toulouse, France. Super OMVs to deliver toxins and PAMPS and block autophagic flux of the host cell

Keynote lecture supported by the Biochemical Society
| 11:00 – 12.00 | Teresa Frisan, 

University of Umeå, Sweden. Tissue microenvironment and bacterial genotoxins: an intricated liaison

| 12.00 – Close |  ETOX 2025 announcement and Close from Organisers

| 12:30 – 13:30 | Lunch 

| 14.00 |  Buses depart