ETOX 2021

June 28 - July 01, 2021, Program

All times are Central European Time CET


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Day 1 - Monday, June 28, 2021 

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| 14:00 – 14:05 | Opening remarks of Chair, Stefan Raunser, MPI of Molecular Physiology, Germany
 
| 14:05 – 14:55 | Keynote lecture: Joseph Mougous, University of Washington, Seattle, USA
Interbacterial toxins in war and peace: harnessing molecular insights for biotechnology

| 14:55 – 15:00 | Break

| 15:00 – 17:00 | Virtual Session 1 - Diversity of bacterial toxins and their functions 
Chair: Vassilis Koronakis, University of Cambridge, UK

| 15:00 – 15:25 | Nick Waterfield, University of Warwick, UK
Extracellular Contractile Injection Systems

| 15:25 – 15:50 | Holger Barth, University of Ulm, Germany
The human peptidome provides novel inhibitors against clostridial enterotoxins

| 15:50 – 16:15 | Susan Lea, National Cancer Institute, USA
Shared architectures for motility and secretion - structural constraints and opportunities

| 16:15 – 16:40 | Ana do Vale (Nuno M.S. dos Santos), University of Porto, Portugal
Photobacterium deadly duet: structure and activity of a novel virulence-associated binary toxin

| 16:40 – 17:00 | Short talks selected from submitted abstracts  
 

Shivneet Gill, University of Toronto, Canada 

Structural Insights to the Human Adaptation of Diphtheria Toxin 

Dukas Jurenas, CNRS - Aix Marseille Université, France 

Photorhabdus secreted T6SS Toxin Inhibits Ribosome Function through 

specific ADP-ribosylation 


| 17:00 – 17:15 | Break

| 17:15 – 18:15 | Virtual Poster Session 1  including live chats and recorded flash talks from poster presenters

| 18:15 – 19:15 | Virtual bar mixer in breakout rooms

Day 2, Tuesday, June 29, 2021

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| 14:00 – 16:40 | Virtual Session 2 - Mechanism of action of toxins 
Chair: Marek Basler, Biozentrum Basel, Switzerland

| 14:00 – 14:25 | Michael Landsberg, University of Queensland, Australia
Structure, function and evolution of the orally active insecticidal toxin complex, YenTc

| 14:25 – 14:50 | Remi Fronzes, CNRS, France
Toxin delivery by the type 6 secretion system in pathogenic E. coli

| 14:50 – 15:15 | Pål Stenmark, Lund University, Sweden
Structure and pH stability of botulinum neurotoxin X in complex with NTNH

| 15:15 – 15:30 | Break

| 15:30 – 15:55 | Melanie Ohi, University of Michigan, Ann-Arbor, USA
Cryo-EM analysis of type IV secretion systems

| 15:55 – 16:20 | Borden Lacy, Vanderbilt University, USA
Structures and Functions of the Clostridioides difficile Toxins

| 16:20 – 16:40 | Short talks selected from submitted abstracts
 

Alexander Belyy, MPI of Molecular Physiology, Germany 

Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from 

bacterial human pathogens 

Daniel Roderer, Leibniz Forschungsinstitut für Molekulare Pharmakologie 

(FMP), Germany 

Kinetics, intermediates, and probability modulation of Tc toxin pore formation 



| 16:40 – 17:00 | Break

| 17:00 – 19:20 | Virtual Session 3 - Pathogenesis and immune responses  
Chair: Juliane Bubeck Wardenburg
, Washington University, USA

| 17:00 – 17:25 | Hao Wu, Harvard Medical School, USA
Making the pore for cytokine secretion

| 17:25 – 17:50 | Daniel Humphreys, Sheffield University, UK
Host senescence: a novel hijack target of Salmonella Typhi

| 17:50 – 18:15 | Giampietro Schiavo, UCL, UK 

Role of SNARE proteins in pathological tau release and propagation 


 | 18:15 – 18:30 | Break

| 18:30 – 18:55 | Kim Orth, UT Southwestern, USA
Vibrio Virulence Regulated by Bile 


 | 18:55 – 19:20 | Jawid Nazir Ahmad (Peter Sebo), CAS, Czechia
Bordetella pertussis adenylate cyclase toxin subverts monocyte differentiation

Day 3, Wednesday, June 30, 2021

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| 14:00 – 16:00 | Virtual Session 4 -Host-pathogen interactions  
Chair: Carmen Buchrieser
, Institut Pasteur, France

| 14:00 – 14:25 | Christoph Dehio, Biozentrum Basel, Switzerland
Translocation of a widely distributed acetyltransferase by different effector translocation systems

| 14:25 – 14:50 | Armelle Menard, Bordeaux University, France
Bacterial genotoxins, cytolethal distending toxin and colibactin, modulate cell survival and differentiation

| 14:50 – 15:15 | Sarah Coulthurst, University of Dundee, UK
Anti-microbial effectors deployed by the Type VI secretion system of Serratia marcescens

| 15:15 – 15:40 | Min Dong, Harvard Medical School, USA
Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform cures botulism in mouse models

| 15:40 – 16:00 | Short talks selected from submitted abstracts
 

Rongshen Jin, University of California, USA 

Structural basis for CSPG4 as a key receptor and therapeutic target for C. 

difficile toxin B 

Justine Toinon, Institut de Biologie de l'Ecole Normale Supérieure, France 

A type IV secreted effector from Legionella pneumophila directly interacts with 

human Argonautes to suppress miRNA- and siRNA-guided gene silencing 


| 16:00 – 16:30 | Break

| 16:30 – 17:30 | Virtual Poster Session 2  including live chats and recorded flash talks from poster presenters

| 17:30 – 17:45 | Break

| 17:45 – 19:00 | Panel Discussion: Quo vadis toxinology? Karla Satchell, Holger Barth, Giampietro Schiavo, Min Dong, Borden Lacy  
Chair: Peter Sebo
, CAS, Czechia

Day 4, Thursday, July 01, 2021

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| 14:00 – 16:40 | Virtual Session 5 - Pathogenesis and immune responses/Applications 
Chair: Teresa Frisan,
Umeå University, Sweden

| 14:00 – 14:25 | Elizabeth Hartland, Monash University, Australia
Diverse mechanisms of host cell control by intracellular bacterial pathogens

| 14:25 – 14:50 | Feng Shao, NIBS, Beijing, China 
A Bacterial Effector Reveals the V-ATPase ATG16L1 Axis that Initiates Xenophagy 


| 14:50 – 15:15 | Petra Dersch, Münster University, Germany 
The molecular function of cytotoxic necrotizing factor (CNFY) and its role in remodelling

Yersinia-host interactions



 | 15:15 – 15:30 | Break

 | 15:30 – 15:55 | Christian Hedberg, Umeå University, Sweden
Identification of Fic enzyme substrates by covalent capture

| 15:55 – 16:20 | Robert Abramovitch, Michigan State University, USA
Targeting two component systems to inhibit Mycobacterium tuberculosis pathogenesis

| 16:20 – 16:45 | Break

| 16:45 – 17:35 | Keynote lecture: Karla Satchell, Northwestern University, USA
MARTX toxins - M stands for Multifunctional

| 17:35 – 17:45 | Closing remarks and poster prizes
Stefan Raunser, MPI of Molecular Physiology, Germany         

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